Glycoside hydrolase family 108

Glycosyl hydrolase 108
Identifiers
Symbol Glyco_hydro_108
Pfam PF05838
Pfam clan CL0037
CAZy GH108

In molecular biology, glycoside hydrolase family 108 is a family of glycoside hydrolases.

Glycoside hydrolases EC 3.2.1. are a widespread group of enzymes that hydrolyse the glycosidic bond between two or more carbohydrates, or between a carbohydrate and a non-carbohydrate moiety. A classification system for glycoside hydrolases, based on sequence similarity, has led to the definition of >100 different families.[1][2][3] This classification is available on the CAZy(http://www.cazy.org/GH1.html) web site,[4] and also discussed at CAZypedia, an online encyclopedia of carbohydrate active enzymes. [5]

Glycoside hydrolase family 108 CAZY GH_108 includes enzymes with lysozyme (N-acetylmuramidase) EC 3.2.1.17 activity. A glutamic acid residue within a conserved Glu-Gly-Gly-Tyr motif is essential for catalytic activity.[6] In bacteria, it may activate the secretion of large proteins via the breaking and rearrangement of the peptidoglycan layer during secretion.[7][8]

References

  1. ^ Henrissat B, Callebaut I, Mornon JP, Fabrega S, Lehn P, Davies G (1995). "Conserved catalytic machinery and the prediction of a common fold for several families of glycosyl hydrolases". Proc. Natl. Acad. Sci. U.S.A. 92 (15): 7090–7094. doi:10.1073/pnas.92.15.7090. PMC 41477. PMID 7624375. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=41477. 
  2. ^ Henrissat B, Davies G (1995). "Structures and mechanisms of glycosyl hydrolases". Structure 3 (9): 853–859. doi:10.1016/S0969-2126(01)00220-9. PMID 8535779. 
  3. ^ Bairoch, A. "Classification of glycosyl hydrolase families and index of glycosyl hydrolase entries in SWISS-PROT". 1999.
  4. ^ Henrissat, B. and Coutinho P.M. "Carbohydrate-Active Enzymes server". 1999.
  5. ^ CAZypedia, an online encyclopedia of carbohydrate-active enzymes.
  6. ^ Stojković EA, Rothman-Denes LB (2007). "Coliphage N4 N-acetylmuramidase defines a new family of murein hydrolases.". J Mol Biol 366 (2): 406–19. doi:10.1016/j.jmb.2006.11.028. PMID 17174325. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=17174325. 
  7. ^ Pei J, Grishin NV (2005). "COG3926 and COG5526: a tale of two new lysozyme-like protein families.". Protein Sci 14 (10): 2574–81. doi:10.1110/ps.051656805. PMC 2253296. PMID 16155206. http://www.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&tool=sumsearch.org/cite&retmode=ref&cmd=prlinks&id=16155206. 
  8. ^ Kondo Y, Toyoda A, Fukushi H, Yanase H, Tonomura K, Kawasaki H et al. (1994). "Cloning and characterization of a pair of genes that stimulate the production and secretion of Zymomonas mobilis extracellular levansucrase and invertase.". Biosci Biotechnol Biochem 58 (3): 526–30. PMID 7764692.